Update on Pharmacology
نویسندگان
چکیده
S STUDIES have shown the important role acetylcholine pathways and transmission play for improving cognitive functions after sustained injuries.1,2 These results opened the way to test the efficacy of acetylcholinesterase inhibitors (AChEIs), among other drugs, for cognitive rehabilitation after traumatic brain injury (TBI). Early studies reported encouraging findings on the efficacy of first-generation AChEIs such as physostigmine.3,4 Newer and safer AChEIs have since been developed for the treatment of Alzheimer’s disease. However, the evidence supporting the off-label use of AChEIs for the rehabilitation of cognitive impairments sustained after TBI is scarce. We systematically reviewed all the published evidence concerning the efficacy and safety of AChEIs for the rehabilitation of cognitive impairments after TBI. Preliminary searches on electronic databases indicated that donepezil was practically the
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تاریخ انتشار 2008